n Cardiovascular Journal of South Africa - Preserve trial surprises with unexpected results on LV hypertrophy reduction with calcium channel blockers : drug trends in cardiology

Volume 13, Issue 1
  • ISSN : 1680-0745



Extracted from text ... The PRESERVE Trial1 (Prospective Randomised Enalapril Study Evaluatory Regression of Ventricular Enlargement) was designed to test the hypothesis that enalapril achieves greater LV regression than nifedipine at equivalent blood pressure reduction. This trial provides the largest prospective, randomised, double-blind study to date, comparing cardiac effects of ACE inhibition and calcium channel blockade in patients with hypertensive LV hypertrophy. The most important result of the study was that regimens based on oncedaily administration of enalapril or long-acting nifedipine significantly reduced LV mass index and relative wall thickness during one year of treatment: LV mass index was reduced to the normal range ..

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