n Cardiovascular Journal of South Africa - Do all NSAIDs modulate aspirin's cardioprotective effects? : drug trends in cardiology

Volume 13, Issue 3
  • ISSN : 1680-0745



Extracted from text ... Do all NSAIDs modulate aspirin's cardioprotective effects? A recent pharmacodynamic study of the interactions between NSAIDs and aspirin in healthy volunteers has shown that commonly used analgesics may modulate the cardioprotective effects of low-dose aspirin to differing degrees. 1 In this evaluation, ibuprofen competitively reduced the sustained inhibitory effect on platelets that underlies the cardioprotective property of aspirin. This did not however occur with delayed-release diclofenac when given with an enteric-coated aspirin (81 mg), or with the cyclo-oxygenase- 2 inhibitor rofecoxib when given with aspirin. These results may be of value to clinicians who wish ..

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