n Cardiovascular Journal of South Africa - Case : control association studies of complex disease : is the search for genetic determinants a fishing expedition? : editorial




Extracted from text ... The mechanisms underlying many of the common, complex diseases that afflict mankind, such as hypertension, diabetes and asthma, remain elusive, despite the promise of spectacular advances through molecular biology and genetics. 1, 2 This failure stands in stark contrast to the avalanche of successes reported almost daily in the search for the genetic variants that cause the much rarer and aetiologically simpler Mendelianly inherited diseases, such as long QT syndrome (LQTS), hypertrophic cardiomyopathy and Marfan's syndrome. 3 However, for the majority of disorders ..


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