n Cardiovascular Journal of South Africa - Cardiovascular risk reduction with pioglitazone : drug trends in cardiology




Extracted from text ... Cardiovascular risk reduction with pioglitazone Type 2 diabetes is associated with a characteristic pattern of lipid abnormalities. Features of the dyslipidaemia include elevated triglycerides and reduced levels of highdensity lipoprotein (HDL). Plasma levels of lowdensity lipoprotein (LDL) do not differ from those of nondiabetic people, but there is a qualitative change in that there is an increase in triglyceriderich small, dense LDL particles. Coupled with hyperglycaemia, these lipid abnormalities are associated with an increased risk of cardiovascular complications. The thiazolidinediones (TZDs) are a relatively new class of oral hypoglycaemic agents, which provide effective longterm glycaemic control in patients with type 2 ..


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