n Cardiovascular Journal of South Africa - Glimepiride well tolerated in daily practice : drug trends in cardiology

Volume 13, Issue 4
  • ISSN : 1680-0745



Extracted from text ... Glimepiride well tolerated in daily practice The efficacy and tolerability of glimepiride (Amaryl) has recently been highlighted in an extensive study of more than 20 000 patients with type 2 diabetes attending 4 000 primary care practices in Germany. Glimepiride is classed as a sulphonylurea for the oral therapy of type 2 diabetes mellitus. Its main action is the release of insulin from pancreatic ? cells. Glimepiride specifically binds to a membrane protein close to the potassium channel of the ? cell membrane and reduces the opening probability of this channel. The resulting depolarisation opens voltagedependent calcium channels and ..

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