n Cardiovascular Journal of South Africa - Not all progestogens are the same : drug trends in cardiology




Extracted from text ... Not all progestogens are the same The Women's Health Initiative (WHI) study has been widely publicised in the media after the combined equine oestrogen-plus-medroxyprogesterone (CEE/MPA) arm was stopped early due to concerns about an excess of cardiovascular events in this arm. The CEEonly arm has not been discontinued. In their conclusions, the authors of this study note that: 'The results do not necessarily apply to lower dosages of these drugs, to other formulations of oral oestrogens and progestins ...' Furthermore, 'this trial could not distinguish the effects of oestrogen from those of progestin. The effects of progestin may be important ..


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