n Cardiovascular Journal of South Africa - Are all statins created equal? : letter to the editor




Extracted from text ... It is commonly but incorrectly assumed that all statins are equal in all respects. However, they differ in many ways, not only in their pharmacokinetics and drug interactions, but also in their pleiotropic effects. Due to these differences, it may also be that the statins differ in their effect on cardiovascular endpoints and side-effect profiles. The differences between statins, both in vitro and in vivo, are briefly reviewed and summarised. The term 'class-effect' is frequently used to indicate that other drugs within the same class share an effect, or sideeffect, of a drug. While these assumptions very often hold true, ..


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