n Cardiovascular Journal of South Africa - Mechanisms of opioid delta (?) and kappa (κ) receptors' cardioprotection in ischaemic preconditioning in a rat model of myocardial infarction : cardiovascular topics




It has been demonstrated that brief periods of coronary artery occlusion before a prolonged period of sustained occlusion paradoxically protect the myocardium against infarction. The mechanisms involved in this phenomenon, termed 'ischaemic preconditioning' (IPC) are still not clear, although it has been established that opioid receptors are involved. The aim of this study was to probe some of the plausible mechanisms involved in the phenomenon by using an model of myocardial infarction in intact rat, a model that allows electrocardiographic and enzymatic in addition to morphometric evaluation of the development of 24-hour myocardial infarction. Selective opioid ?-receptor agonist (DADLE) and antagonist (natrindole), and opioid κ-receptor agonist (U-50488H) and antagonist (nor-BNI) were used.


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