n Cardiovascular Journal of South Africa - Do ACE inhibitors have a real role in coronary artery disease? : drug trends in cardiology

Abstract

Extracted from text ... Do ACE inhibitors have a real role in coronary artery disease? ACE inhibitors are widely accepted as mainline therapy for hypertension and heart failure - but do they have a part to play in the treatment of coronary artery disease (CAD)? After all, we now know that abnormalities in the renin-angiotensin-aldosterone system (RAAS) are clearly associated with atherosclerosis and the pathogenesis of cardiovascular disease. For example, an increase in activity of the RAAS can lead to a rise in angiotensin II, and to a fall in bradykinin levels. Apart from reducing blood pressure, ACE inhibitors have been shown to inhibit ..