n Cardiovascular Journal of South Africa - The effect of different apo(a) isoforms on plasminogen activation in black South African subjects : cardiovascular topics

Volume 14, Issue 3
  • ISSN : 1680-0745



<i>Objective</i> : The present study evaluates the effect of different apolipoprotein(a) [apo(a)] isoforms on plasminogen activation. <br><i>Design</i> : A cross-sectional study. <br><i>Setting</i> : A rural village (Dikgale district ) in the Northern Province of South Africa. <br><i>Subjects</i> : A total of 90 apparently healthy subjects (64 females and 36 males) aged 43 to 67 years participated in the study. <br><i>Results</i> : The mean lipoprotein(a) [Lp(a)] level in the subjects was 38.14 ± 22.34 mg / dl. No association was found between Lp(a) levels and apo(a) isoforms. When the ratio of Lp(a) : plasminogen was less than 1.3, a competitive inhibition was observed, but when the ratio exceeded 1.3, an uncompetitive inhibition was observed with all isoforms. <br><i>Conclusion</i> : The results of the present study suggest that the inhibition of plasminogen activation by Lp(a) is not dependent on apo(a) size.

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