n Cardiovascular Journal of South Africa - Renin-angiotensin system and associated gene polymorphisms in myocardial infarction in young South African Indians : cardiovascular topics
|Article Title||Renin-angiotensin system and associated gene polymorphisms in myocardial infarction in young South African Indians : cardiovascular topics|
|© Publisher:||Clinics Cardive Publishing|
|Journal||Cardiovascular Journal of South Africa|
|Author||N. Ranjith, R.J. Pegoraro, L. Rom, P.A. Lanning and D.P. Naidoo|
|Publication Date||Jan 2004|
|Pages||22 - 26|
The renin-angiotensin system plays an important role in cardiovascular regulation. Abnormalities in genetic components of this system, such as the angiotensinconverting enzyme (ACE) gene, angiotensin II type 1 (AT<sub>1</sub>) receptor gene and angiotensinogen (AGT) gene, may cause a variety of adverse cardiovascular effects. <br>It was the aim of this study, therefore, to investigate the involvement of the ACE insertion/deletion (I/D), AT<sub>1</sub> receptor 1166 A-->C and AGT M235T polymorphisms as predisposing factors for myocardial infarction (MI) in 195 young South African Indians (<u><</u> 45 years). Results were compared with those obtained in 107 unaffected siblings (18-45 years old) and 300 healthy age- and racematched control subjects. <br>The distribution of the ACE genotypes was the same in each of the three study groups (<i>p</I>-value ranged between 0.83 and 0.98). No differences were observed in the 1166 A-->C AT<sub>1</sub> receptor polymorphism with respect to both genotype and allelotype (<I>p</I> > 0.70), or in the genotype or allele frequency distribution of the AGT M235T polymorphism (<I>p</I> > 0.44). However, a significant increase was noted for both the AT<sub>1</sub> receptor C variant (<I>p</I> = 0.025) and the AGT T variant (<I>p</I> = 0.047) in hypertensive patients compared with those who were normotensive. <br>In conclusion, results of this study indicate that the ACE I/D, the 1166 A-->C AT<sub>1</sub> receptor and AGT M235T polymorphisms do not confer any increased risk for MI in young South African Indians.
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