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n Cardiovascular Journal of South Africa - Renin-angiotensin system and associated gene polymorphisms in myocardial infarction in young South African Indians : cardiovascular topics

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Abstract

The renin-angiotensin system plays an important role in cardiovascular regulation. Abnormalities in genetic components of this system, such as the angiotensinconverting enzyme (ACE) gene, angiotensin II type 1 (AT<sub>1</sub>) receptor gene and angiotensinogen (AGT) gene, may cause a variety of adverse cardiovascular effects. <br>It was the aim of this study, therefore, to investigate the involvement of the ACE insertion/deletion (I/D), AT<sub>1</sub> receptor 1166 A-->C and AGT M235T polymorphisms as predisposing factors for myocardial infarction (MI) in 195 young South African Indians (&lt;u&gt;&lt;&lt;/u&gt; 45 years). Results were compared with those obtained in 107 unaffected siblings (18-45 years old) and 300 healthy age- and racematched control subjects. <br>The distribution of the ACE genotypes was the same in each of the three study groups (<i>p</I>-value ranged between 0.83 and 0.98). No differences were observed in the 1166 A-->C AT&lt;sub&gt;1&lt;/sub&gt; receptor polymorphism with respect to both genotype and allelotype (&lt;I&gt;p&lt;/I&gt; > 0.70), or in the genotype or allele frequency distribution of the AGT M235T polymorphism (&lt;I&gt;p&lt;/I&gt; > 0.44). However, a significant increase was noted for both the AT&lt;sub&gt;1&lt;/sub&gt; receptor C variant (&lt;I&gt;p&lt;/I&gt; = 0.025) and the AGT T variant (&lt;I&gt;p&lt;/I&gt; = 0.047) in hypertensive patients compared with those who were normotensive. <br>In conclusion, results of this study indicate that the ACE I/D, the 1166 A-->C AT&lt;sub&gt;1&lt;/sub&gt; receptor and AGT M235T polymorphisms do not confer any increased risk for MI in young South African Indians.

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/content/cardio/15/1/EJC23880
2004-01-01
2016-12-05
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