n Cardiovascular Journal of South Africa - New developments in pharmacotherapy : editorial




Extracted from text ... 56 New developments in pharmacotherapy The latest developments in the lipid-regulating drug field have been the launching of rosuvastatin, arguably the most potent statin currently available and of ezetimibe, a novel cholesterol absorption inhibitor. Combined administration of these two classes of drug achieves simultaneous inhibition of cholesterol synthesis and absorption, resulting in unprecedented reductions in low-density lipoprotein (LDL). Inhibition of cholesterol synthesis The discovery of statins 30 years ago1 has revolutionised the management of dyslipidaemia. These drugs competitively inhibit HMG-CoA reductase, thereby reducing cholesterol synthesis in the liver; this leads to an increased expression of hepatic LDL receptors and greater ..


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