n Cardiovascular Journal of South Africa - Fixed-combination therapy for hypertension increases success rate : drug trends in cardiology

Volume 15, Issue 5
  • ISSN : 1680-0745



Extracted from text ... Hypertension is by no means a simple condition, but the end-result of a complex interplay between blood pressureregulating mechanisms. As such, hypertensive patients are unlikely to respond adequately to the use of a single therapeutic agent.1, 2 Even at high doses, a normalisation rate of only 20-50% is reported when using a single agent, 3, 4 and at half-maximal levels, the responder rate plummets to 9-10%.5 In patients with diabetes or nephropathy, where lower target blood pressures are needed, even lower normalisation has been achieved. Monotherapy is often discontinued in a disturbingly high percentage of patients.4 In fact, singleagent therapy ..

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