n Cardiovascular Journal of South Africa - CHARM study in CHF patients with impaired LV function reinforces benefits of candesartan cilexetil (Atacand(R)) : drug trends in cardiology

Volume 15, Issue 5
  • ISSN : 1680-0745



Extracted from text ... 252 Further analysis of the CHARM study focusing on patients with chronic heart failure (CHF) and impaired LV function in the CHARM-Alternative trial (patients received candesartan instead of an ACE inhibitor) and CHARMAdded (patients receiving candesartan plus ACE inhibitor) has shown a significant reduction in deaths and CHF hospital admissions in patients receiving this angiotensin-receptor blocker. The overall CHARM programme, announced at the European Society Congress (ESC) last year, had included a third, CHARM-Preserved trial, which investigated CHF patients with uncompromised left ventricular ejection fraction (LVEF above 40%). The pre-specified analysis of the 4 576 CHARM patients with heart failure ..

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