n Cardiovascular Journal of South Africa - Cellular injury in ischaemia : editorial comment

Abstract

Extracted from text ... Most presentations (given by internationally renowned researchers in the field) focused on subcellular and molecular aspects of myocardial injury in ischaemia and heart failure, as well as cardioprotection, many presenters contextualised their work in terms of bridging the gap between the basic sciences and the clinical situation, as indicated below. Although many mechanisms contribute to ischaemic injury, there is now clear evidence that contractile dysfunction during and after myocardial ischaemia is mediated, in part, by changes in myocardial metabolism, as reflected by abnormally high rates of fatty acid oxidation which occurs at the expense of glucose oxidation. Therefore, a new ..