n Cardiovascular Journal of South Africa - A closer look at the ACTION study in the hypertensive sub-group : drug trends in cardiology




Extracted from text ... 132 CARDIOVASCULAR JOURNAL OF SOUTH AFRICA Vol 16, No. 2, March/April 2005 The ACTION study was initiated in response to the debate in the 1990s about the safety of calcium antagonists in particular in patients with coronary artery disease. It was designed to access the effect of nifedipine GITS on clinical outcome in patients with stable angina irrespective of blood pressure level at baseline. In clinical practice, coronary artery disease and hypertension often occur concurrently. In ACTION, 52% of the 8 000 patients had baseline blood pressures =?140/90 mmHg. The main conclusion of the ACTION study was that nifedipine GITS is ..


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