n Cardiovascular Journal of South Africa - The effect of angiotensin receptor blockers on myocardial infarction : what are we to believe? : editorial




Extracted from text ... CARDIOVASCULAR JOURNAL OF SOUTH AFRICA Vol 16, No. 2, March/April 2005 81 Blood pressure increases that are above optimum levels contribute about one-half of the burden of ischaemic heart disease.1 Lowering the blood pressure has beneficial effects on major cardiovascular events.2 There is, however, still uncertainty about the comparative effects of different drug regimens targeting different blood pressure goals.3 In a recent meta-analysis of four major angiotension receptor blocker (ARB) trials (n = 16 791 patients), comparing ARBs to other active therapy, the Blood Pressure Lowering Treatment Trialists' Collaboration Group demonstrated the following effect on coronary artery disease: 435/8 412 ..


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