n Cardiovascular Journal of South Africa - Lovastatin - candidate for non-prescription availability in US market : drug trends in cardiology




Extracted from text ... A recent review of two decades of use of lovastatin in the United States has highlighted the extremely low risk of myopathy1 and rhabdomyolysis associated with the use of this statin. Myopathy is a reversible, adverse drug reaction associated with all statins and defined as a serum creatine kinase (CK) level more than 10 times the upper limit of normal (ULN), with muscle symptoms. Rhabdomyolysis is the most severe form of myopathy, recently defined as muscle symptoms with marked CK elevation (typically substantially more than 10 times the ULN). The risk for lovastatin-associated muscle disease is best evaluated by data from ..


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