n Cardiovascular Journal of South Africa - Plaque composition changes on rosuvastatin treatment : drug trends in cardiology

Volume 16, Issue 3
  • ISSN : 1680-0745



Extracted from text ... A novel study undertaken to examine the effect of statins on the composition of plaques, using high-resolution MRI, has shown that rosuvastatin treatment resulted in regression of the proportion of the lipid-rich necrotic core in the most diseased location of the atherosclerotic plaque.1 In this trial, expert readers who were blinded to dosage and time sequences, reviewed the scans, examining the effects of two years of treatment with low (5-mg) or high (40-mg) rosuvastatin doses. Thirty-five subjects had matched baseline and two-year scans. Cholesterol lowering was effective: LDL-C was reduced from baseline by 39 and 58% in the 5-mg and 40-mg ..

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