1887

n Cardiovascular Journal of South Africa - Coagulation gene polymorphisms as risk factors for myocardial infarction in young Indian Asians : cardiovascular topic

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Abstract

&lt;I&gt;Background:&lt;/I&gt; The relationship between pro-coagulant gene polymorphisms, clinical features and the risk of premature coronary heart disease (CHD) in Indian Asian subjects resident in South Africa has been investigated. &lt;BR&gt;&lt;I&gt;Methods:&lt;/I&gt; The prevalence of the <SPAN lang=AF style="FONT-FAMILY: Symbol; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'; mso-char-type: symbol; mso-symbol-font-family: Symbol"><SPAN style="mso-char-type: symbol; mso-symbol-font: Symbol">b</SPAN></SPAN>-fibrinogen -455G/A and -148C/T, and the factor VII 10bp 5' promoter insertion/deletion and R353Q polymorphisms were examined in 195 unrelated Indian Asian patients (&lt;u&gt;&lt;&lt;/u&gt; 45 years) who presented with myocardial infarction (MI). Results were compared with those from 107 unaffected siblings (18-45 years) and 300 healthy age- and race-matched control subjects. &lt;BR&gt;&lt;I&gt;Results:&lt;/I&gt; Overall, none of the polymorphisms examined here showed any association with MI. However, when stratified according to obesity, patients with a BMI > 30 kg/m&lt;sup&gt;2&lt;/sup&gt; had a significantly higher frequency of the <SPAN lang=AF style="FONT-FAMILY: Symbol; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'; mso-char-type: symbol; mso-symbol-font-family: Symbol"><SPAN style="mso-char-type: symbol; mso-symbol-font: Symbol">b</SPAN></SPAN>-fibrinogen variant alleles, compared with non-obese patients (19% vs 9%; &lt;I&gt;p&lt;/I&gt; = 0.025) and controls (19% vs 9%; &lt;I&gt;p&lt;/I&gt; = 0.003). Furthermore, the highest frequency of variant alleles occurred in obese smokers (24%), compared with 4% in non-obese non-smokers (&lt;I&gt;p&lt;/I&gt; = 0.003) and 9% in control subjects (&lt;I&gt;p&lt;/I&gt; < 0.001). The factor VII R353Q and promoter insertion variants, on the other hand, were associated with higher HDL and lower LDL levels (&lt;I&gt;p&lt;/I&gt; = 0.034 and 0.04, respectively). &lt;BR&gt;&lt;I&gt;Conclusion:&lt;/I&gt; In young Indian Asians who are both obese and smoke, the <SPAN lang=AF style="FONT-FAMILY: Symbol; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'; mso-char-type: symbol; mso-symbol-font-family: Symbol"><SPAN style="mso-char-type: symbol; mso-symbol-font: Symbol">b</SPAN></SPAN>-fibrinogen genetic polymorphisms -455G-->A and -148C-->T, which are in linkage disequilibrium, are significant risk factors for the development of MI. Factor VII genetic variants, namely the 10bp promoter insertion/deletion and R353Q polymorphisms, may possibly play a protective role through their association with elevated HDL and low LDL levels, respectively.

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/content/cardio/16/3/EJC24006
2005-05-01
2016-12-05
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