n Cardiovascular Journal of South Africa - Two- and three-drug therapy with candesartan cilexetil (Atacand®) successful in patients with severe hypertension : drug trends

Volume 16, Issue 5
  • ISSN : 1680-0745



A recent double-blind study of the treatment of hypertensive patients whose blood pressure remained above target on two-drug combinations, showed that a strategy of adding candesartan cilexetil (Atacand®) or of switching to candesartan and hydrochlorothiazide produced further reductions in blood pressure while maintaining tolerability. In addition, the results showed a trend in favour of the three-drug, standard-dose approach, compared to the two-drug, high-dose approach.

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