n Cardiovascular Journal of South Africa - PROactive study shows reduced heart attacks and strokes in type 2 diabetics on pioglitazone HCI (Actos®) therapy : drug trends

Volume 16, Issue 5
  • ISSN : 1680-0745



The ambitious PROactive study, initiated in 2001, is the first prospective, randomised, double-blind, placebo-controlled trial of an oral glucose-lowering medication's ability to significantly improve cardiovascular outcomes over 2.5 years of therapy in type 2 diabetics. The study added pioglitazone to the treatment of type 2 diabetics who were already receiving standard-care therapy including dietary modification, glucose lowering (using metformin, sulphonylureas and insulin), blood pressure regulation, lipid lowering and antithrombotic agents, according to the 1999 IDF (European) guidelines.

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