n Cardiovascular Journal of South Africa - Homocysteine in vascular disease : an emerging clinical perspective : review article
|Article Title||Homocysteine in vascular disease : an emerging clinical perspective : review article|
|© Publisher:||Clinics Cardive Publishing|
|Journal||Cardiovascular Journal of South Africa|
|Author||Peter Jacobs, Lucille Wood and Rodger Bick|
|Publication Date||May 2006|
|Pages||135 - 139|
Traditionally, arterial and venous thrombo-embolism has been attributed to pathophysiological lesions in the vessel wall, or altered blood contents or flow through the lumen. Logically these fall into the category of a high-shear system, as opposed to the rather different circumstances in slowly moving columns of blood. The re-evaluation of this belief has been prompted by acknowledgement that there is currently a shift in emphasis. Recently we have recognised a common central factor in the internal dysfunction of the vessel that precedes and so initiates thrombocyte adhesion.
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