n Cardiovascular Journal of Africa - Peripartum cardiomyopathy and familial dilated cardiomyopathy : a tale of two cases : online article - case report

Volume 24, Issue 5
  • ISSN : 1995-1892
  • E-ISSN: 1680-0745



Peripartum cardiomyopathy (PPCM) is a form of pregnancy-related heart failure that is associated with considerable morbidity and mortality. Most patients present with acute postpartal heart failure that otherwise resembles the clinical presentation of dilated cardiomyopathy (DCM). There is increasing recognition that PPCM may be due to genetic factors in a significant proportion of cases. There is evidence that at least 7% of cases of PPCM may be part of the spectrum of familial DCM. We report on two cases of PPCM, with relatives demonstrating familial DCM, both patients displaying autosomal dominant patterns of inheritance, and showing severe cardiomyopathy among proband and affected relatives. Family screening for familial DCM should be indicated in all cases of unexplained PPCM.

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