1887

n Cardiovascular Journal of Africa - Impact of prehypertension on left ventricular mass and QT dispersion in adult black Nigerians : cardiovascular topic

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Abstract

Prehypertension has been associated withtarget-organ damage. This study sought to determine theimpact of prehypertension (PHT) on QT dispersion and leftventricular hypertrophy (LVH) in adult black Nigerians.


One hundred and one subjects with office blood pressure (BP) < 140/90 mmHg were categorised according to their office BP into normotensive (normal BP < 120/80 mmHg, = 57) and prehypertensive (prehypertensive BP 120-139/80-89 mmHg, = 44) groups. Echocardiography and electrocardiography (ECG) were performed on the subjects.
Thirty-four males aged 53.65 ± 16.33 years and 67 females aged 52.42 ± 12.00 years were studied. The mean QT interval dispersion (QTd) of the normotensive (38.96 ± 11.06 ms) and prehypertensive (38.41 ± 11.81 ms) groups were similar ( = 0.81). Prehypertensive subjects had higher left ventricular mass (LVM) (165.75 ± 33.21 vs 144.54 ± 35.55 g, = 0.024), left ventricular mass index 1 (LVMI-1) (91.65 ± 16.84 vs 80.45 ± 18.65 g/m2, = 0.021) and left ventricular mass index 2 (LVMI-2) (54.96 ± 10.84 vs 47.51 ± 12.00 g/m2.7, = 0.017). QTd was independent of echocardiographic and electrocardiographic LVH ( > 0.05).
Compared with normotension, prehypertension is associated with higher LVM but similar QTd. This suggests that structural remodelling precedes electrical remodelling in prehypertension.

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/content/cardio1/25/2/EJC151895
2014-03-01
2016-12-09
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