n Cardiovascular Journal of Africa - The proposed role of plasma NT pro-brain natriuretic peptide in assessing cardiac remodelling in hypertensive African subjects : cardiovascular topic

Volume 25, Issue 5
  • ISSN : 1995-1892
  • E-ISSN: 1680-0745



Although plasma NT-proBNP differentiates hypertension (HT) with or without left ventricular hypertrophy (LVH) from hypertensive heart failure (HHF), most of the published data are based on studies in Western populations. Also, most previous studies did not consider left ventricular (LV) diastolic function and right ventricular (RV) function. We therefore examined the relation between NT-proBNP on LV and RV remodelling in an African hypertensive cohort.

Subjects were subdivided into three groups after echocardiography: hypertensives without LVH (HT) ( = 83); hypertensives with LVH (HT+LVH) ( = 50); and those with hypertensive heart failure (HHF) ( = 77).
Subjects with HHF had significantly higher NT-proBNP levels compared to the HT+LVH group ( < 0.0002). NT-proBNP correlated positively with right atrial area, an indirect measure of RV function.
NT-proBNP is proposed as a useful biomarker in differentiating hypertension with or without LVH from hypertensive heart failure in black hypertensive subjects.

Loading full text...

Full text loading...


Article metrics loading...


This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error