oa Cardiovascular Journal of Africa - The extent of progressive familial heart block type 1 - a new perspective
|Article Title||The extent of progressive familial heart block type 1 - a new perspective|
|© Publisher:||Clinics Cardive Publishing|
|Journal||Cardiovascular Journal of Africa|
|Affiliations||1 Department of Paediatrics and Child Health and Cardiac Unit, Tygerberg Hospital and University of Stellenbosch, Cape Town.|
|Publication Date||Jun 1994|
|Pages||125 - 126|
|Keyword(s)||New perspective and Progressive familial heart block type 1|
New data on the inheritance of progressive familial heart block type 1 (PFHB1) does not favour the theory that the original immigrant (founder of PFHB1 families) introduced the genetic abnormality into South Africa and suggests that a new mutation in family member b6 (Fig. 1) was possibly responsible for the origin of the disease. If the mutation occurred in family member b6, this would reduce the number of affected family members from a previously estimated 9 000 to a mere 860 with a revised prevalence of 1:5 000 South Africans of European descent.
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