oa Cardiovascular Journal of Africa - Ischaemic preconditioning - laboratory phenomenon or relevant to clinical practice?



Protection against myocardial infarction (MI) has always been an important goal in cardiology, since the cell damage is irreversible, and the morbidity and mortality in patients who suffer MI correlate directly with the size of the infarct. Numerous strategies have been shown to protect the heart against ischaemia in experimental animals, such as use of calcium blockers and anti-oxidants, but clinical trials have not been able to prove any such beneficial effects.


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