This study examined the effect of 0,6 % halothane on reperfusion myocardial injury in pig hearts with a coronary artery stenosis. Ten animals were anaesthetised with thiopental and fentanyl and were mechanically ventilated. Anaesthesia was maintained with either 0,6% halothane (N = 5) or a constant infusion of opiate (fentanyl)-pentobarbital (OP) (N = 5). Aortic pressure and cardiac output were measured and regional myocardial function studied with end-systolic pressure-length ratios, regional systolic shortening and post-systolic shortening. After control measurements, a stenosis was applied to the left anterior descending (LAD) coronary artery. This was followed by total occlusion of the LAD artery for 15 minutes and reperfusion for 3 hours with the stenosis still applied to the LAD artery.
Bretschneider HTK-solution is frequently used for myocardial preservation. In order to evaluate its protective effect in heart transplantation we initiated a retrospective study in co-operation with Eurotransplant. Sixty-four female and 95 male patients, who were transplanted between 1985 and 1991 at our institution, were included in this study. We collected important data on donors and recipients, such as labaratory data, and data on immunosuppressive therapy and pre-, intra- and postoperative organ function.
Transplantation of the lung has become a reality during the past decade. Recent developments include expanded indications for lung transplantation and the increased use of single- and double-lung transplantation rather than heart-lung transplantation. Candidate selection criteria, patient management and results of heart-lung, single-lung and double-lung transplantation are reviewed.
Three cases of idiopathic subannular mitral valve aneurysm are descriptionbed in children of mixed ethnic origin. Initially these defects were only descriptionbed in black patients and were thought to be genetically induced. Lately a few cases of these abnormalities were descriptionbed in white patients, making the genetic basis of this abnormality unlikely. All 3 patients presented with mitral valve incompetence and cardiac failure and it is therefore crucial that subannular aneurysms of the left ventricle be considered in the differential diagnosis in children who have mitral valve incompetence with no obvious underlying cause.