oa Cardiovascular Journal of Africa - Reperfusion injury in the presence of a coronary artery stenosis



This study examined the effect of 0,6 % halothane on reperfusion myocardial injury in pig hearts with a coronary artery stenosis. Ten animals were anaesthetised with thiopental and fentanyl and were mechanically ventilated. Anaesthesia was maintained with either 0,6% halothane (N = 5) or a constant infusion of opiate (fentanyl)-pentobarbital (OP) (N = 5). Aortic pressure and cardiac output were measured and regional myocardial function studied with end-systolic pressure-length ratios, regional systolic shortening and post-systolic shortening. After control measurements, a stenosis was applied to the left anterior descending (LAD) coronary artery. This was followed by total occlusion of the LAD artery for 15 minutes and reperfusion for 3 hours with the stenosis still applied to the LAD artery.


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