oa Cardiovascular Journal of Africa - Halothane anaesthesia is associated with improved post-cardiopulmonary bypass global myocardial function

Volume 6, Issue 2
  • ISSN : 1995-1892
  • E-ISSN: 1680-0745



This study compared the effect of halothane and opiate anaesthesia on myocardial necrosis and reperfusion injury after coronary artery bypass surgery in patients. Except for the halothane and opiates, a similar anaesthetic technique was used in the two groups (10 patients each), including pre-induction beta-adrenergic blockade. The demographic data of the groups were similar and results indicated that there was no difference in the incidence of post-cardiopulmonary bypass arrhythmias. The creatine kinase myocardial fraction (CK-MB) in both groups increased after induction of anaesthesia (from 2,6 � 0,9 to 5,6 � 1,5%, mean and SEM for the opiate group and 1,3 � 0,2 to 7,8 � 1,7% for halothane patients).

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