oa Cardiovascular Journal of Africa - Histological morphometry as an independent means of distinguishing left ventricular hypertrophy induced by systemic hypertension and dilated (congestive) cardiomyopathy



This study investigated the possibility that, independently of other criteria, light microscopic bivariate morphometry could distinguish between the histologically similar myofibre pathology extant in dilated (congestive) cardiomyopathy (DCM) and systemic hypertension (HYP). Left ventricular tissue, taken at necropsy from the hypertrophic hearts of 30 patients who had died as a consequence of DCM and 18 with HYP, was subjected to bivariate myofibre morphometry. The cross-nuclear fibre diameter (FD) and nuclear diameter (ND) were determined for each of 150 myofibres per specimen and their mean FD/ND co-ordinates plotted. The bivariate relationship between FD and ND for each group of specimens was expressed as linear regressions and the limits for the distribution of DCM specimen means were calculated and depicted in the form of an ellipse.


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