oa Cardiovascular Journal of Africa - Restenosis after coronary angioplasty - a review of the pathogenesis and strategies for prevention



Since Gr�ntzig performed the first successful human percutaneous transluminal coronary angioplasty (PTCA) in 19771 this procedure has become widely used in the non-surgical management of patients with coronary artery disease. While the primary success rate of PTCA is in excess of 90%,2,3, up to 40% of procedures eventually fail as a result of the development of restenosis at the angioplasty site.2,4-6 The importance of this problem is obvious when one considers that, in the USA, more than 300 000 PTCAs are performed annually at a cost of over $15000 each with about 30% of these patients needing repeat angioplasty or bypass grafting within 1 year.7


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