oa Cardiovascular Journal of Africa - Acute pulmonary hypertension and right ventricular failure in adult respiratory distress syndrome

Volume 7, Issue 3
  • ISSN : 1995-1892
  • E-ISSN: 1680-0745



The severity of acute pulmonary hypertension (APHT) in acute respiratory distress syndrome was examined in 20 patients. All patients had significant APHT (mean pressure 40.6 � 6.3 mmHg) on admission to the intensive care unit. There was evidence of right ventricular (RV) failure, with a right ventricular stroke work index (RVSWI) of 9.20 � 3.3 g.m/m2 and a central venous pressure of 18.0 � 4.0 mmHg. The RV afterload, i.e. pulmonary artery elastance (Ea = stroke volume/peak pulmonary artery pressure), was raised. Stroke volume could not be predicted from Ea or RVSWI alone, but regression analysis indicated that the ratio of RVSWI/Ea (i.e. ventriculo-arterial coupling) could account for 88% of the stroke volume.

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