oa Cardiovascular Journal of Africa - Antibiotic therapy in bacterial endocarditis



Despite advances in antimicrobial therapy, endocarditis continues to be a difficult therapeutic problem. In countries where streptococci remain the commonest cause of this disease, penicillin and gentamicin are still the best empirical choices. Studies have allowed some refining of therapy by identifying criteria, on the basis of which decisions can be made about the duration of therapy and the need for synergistic aminoglycosides. In prosthetic endocarditis the preponderance of staphylococci as causative agents dictates the empirical use of vancomycin until sensitivity data are available.


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