oa Cardiovascular Journal of Africa - Thiazide-treated hypertension or type 2 diabetes mellitus - which is the greater potenial coronary risl factor in black South Africans

Volume 7, Issue 5
  • ISSN : 1995-1892
  • E-ISSN: 1680-0745



Type 2 diabetes and essential hypertension are coronary risk factors that are becoming increasingly prevalent among urban black South African communities. To determine whether both disorders generate equivalent dyslipidaemia, we evaluated the serum lipoprotein profile of 50 black obese patients with long-standing hypertension who were receiving low-dose thiazide diuretics and a similar number of black obese type 2 diabetic subjects. Compared to subjects with diabetes, hypertensive patients on diuretics showed significantly higher mean total (5.40 � 1.19 v. 4.93 � 1.08 mmol/l; P < 0.05) and low-density-lipoprotein (3.43 � 1.06 v. 2.90 � 0,79 mmol/l; P < 0.01) cholesterol, although their triglyceride levels were lower (1.23 � 0.55 v. 1.76 � 1.07 mmol/l; P < 0.01). These cholesterol profiles were generally the reverse of trends found in white patients with the same two clinical conditions. Our findings have potential therapeutic implications and suggest that the so-called 'metabolic syndrome' requires different interpretation in an African context.

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