oa Cardiovascular Journal of Africa - HLA-A, -B, and -DQ antigens in black patients with infective endocarditis
|Article Title||HLA-A, -B, and -DQ antigens in black patients with infective endocarditis|
|© Publisher:||Clinics Cardive Publishing|
|Journal||Cardiovascular Journal of Africa|
|Affiliations||1 Department of Experimental and Clinical Pharmacology, University of Natal and the Natal Institue of Immunology, Durban|
|Publication Date||Feb 1998|
|Pages||10 - 12|
|Keyword(s)||Cardiology, Genetics, HLA antigens and Human physiology|
In order to determine if genetically determined immune response factors could play a role in the pathogenesis of infective endocarditis in black patients, we performed HLA-A and HLA-B typing in 38 patients with this disease and HLA-DR and HLA-DQ typing in 33 and 27 of these individuals, respectively. HLA typing was also carried out in a control group of normal black adults. The HLA typing was done by means of a standard microlymphocytotoxicity test. No difference in HLA-A, HLA-B, HLA-DR and HLA-DQ antigen frequencies between patients and controls were noted. This study did not provide any evidence that genetic factors could contribute to a disposition to infective endocarditis.
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