oa Cardiovascular Journal of Africa - Two roles for caveolae in the cardiac myocyte
|Article Title||Two roles for caveolae in the cardiac myocyte|
|© Publisher:||Clinics Cardive Publishing|
|Journal||Cardiovascular Journal of Africa|
|Affiliations||1 Department of Physiology, University of Pretoria|
|Publication Date||Feb 1998|
|Pages||16 - 18|
|Keyword(s)||Ca2+, Calcium ion storage and transport, Calveolae, Cardiology, Excitation-contraction coupling in heart muscle, Exocytosis and Physiology|
The presence of caveolae in many cell types including heart myocytes is well established. It is hypothetised that caveolae may play a role in the storing of excess Ca2+ and may be instrumental in Ca2+ transients during contraction and relaxation' in pathological conditions. Furthermore, the presence of substances in caveolae and in their membranes may imply a role in the importing and exporting of key molecules under physiological and pathological conditions. Secretory activity is also suggested by an electron micrograph of rat heart muscle.
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