oa Cardiovascular Journal of Africa - Effects of halothane on post-cardiplegic functional recovery - the role of cardioplegic solution

Volume 9, Issue 2
  • ISSN : 1995-1892
  • E-ISSN: 1680-0745



Halothane has been shown to be a powerful protectant ,against ischaemic injury. It has also been shown to improve metabolic, functional and structural recovery significantly during reperfusion of hearts previously subjected ""to normothermic cardioplegia,)"" regardless of the mode of its-administration (before and after arrest or intermittently during arrest). In the latter studies a crystalloid solution, Plasmalyte B (to which excess KCI was added) was used as cardioplegic solution. The most likely reason for these beneficial effects of halothane is its effects on intracellular Ca2+ movements; it has been shown to inhibit the accumulation of this ion during ischaemia as well as during reperfusion. In the course of our studies on myocardial protection during cardioplegia we noted that the functional recovery of hearts arrested with St Thomas Hospital (STH) cardioplegic solution was significantly better than that of hearts exposed to Plasmalyte B. In view of the proven efficacy of the former, 7.8 the question arose whether halothane would be able to afford additional protection to hearts arrested with STH. The purpose of this study was therefore to compare the effects of halothane on the functional recovery of hearts subjected to normothermic cardioplegic arrest induced by either Plasmalyte B or STH.

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