This study evaluated blood pressure (BP) measurements utilising three automatic blood pressure measuring devices. BPs of 36 healthy subjects taken with the AND Digital Blood Pressure Meter UA-731, auto-inflating, the AND Digital Blood Pressure Meter UA-701, manual inflating, and the AND Digital Blood Pressure Meter Memory + Printer UA-751, auto-inflating, were compared with measurements taken with the standard mercury sphygmomanometer. Devices UA-731 and UA-701 gave significantly higher systolic BP measurements than the manual method, while measurements taken with the UA-751 did not differ significantly from the manual method. Diastolic measurements using the electronic devices were lower than those determined using the manual method. Only measurements taken by device UA-751 were statistically significantly lower. This study showed that order effect in multiple determinations of BP has to be considered to interpret the data. Using electronic devices for home determination of BP can be very useful, if the patient is trained according to standardized procedures. The same argument holds for epidemiological surveys. A very helpful attribute for epidemiological surveys is that the operator does not have to be a medically trained person, which keeps costs down.
15-(p-[I23I]-iodophenyl)-3-R,S-methylpentadecanoic acid (123I-BMIPP) is a modified branched fatty acid analogue with relatively slow clearance from the heart which renders it suitable to study myocardial fatty acid metabolism with single photon emission computed tomography (SPECT). Myocardial fatty acid uptake is regulated by a variety of factors, including concentrations of potential substrates, cardiac workload and possible ischaemia. Since these factors could be altered by exercise, the purpose of this study was to compare 123I-BMIPP uptake at rest and with exercise in 10 healthy male volunteers. 123I-BMIPP (185MBq) was administered intravenously followed by planar and tomographic imaging with a dua)-headedscintiHation camera. A geometrical mean method including the triple-energy scatter correction technique was used to quantify myocardia) uptake using the planar images. The mean uptakes with respect to the administered dose for the rest and exercise studies were 4.62 ï¿½ 0.98 % and 3.02 ï¿½ 0.58%, respectively. The mean difference was 1.60 ï¿½ 0.83% and the 95% confidence interval was 1.00 - 2.19%. The global myocardia) uptake of 123I-BMIPP was significantly reduced from rest to exercise, but regional redistribution was not observed during the visual interpretation of the images.
A histochemical, morphometric method was employed for sequential investigation of the changes occurring in primate skeletal muscle during the first 24 hours of reperfusion following 3 hours of tourniquet-induced ischaemia. While there was a general reduction in mean fibre diameters after ischaemia, fibre types 1, 2A and 2B were found to respond differently to reperfusion over the experimental period. Type 1 fibres were significantly enlarged after 6, 12, 18 and 24 hours of reperfusion, with type 2A fibres being significantly enlarged after 12, 18 and 24 hours. The trend of enlargement for type 2B fibres did not reach statistical significance. The degree of oedema, expressed as a percentage increase in fibre diameter, varied in the different fibre types, being greatest in type 1 fibres and least in type 2B. These differences in response may reflect the fibre type's metabolic dependence on oxygen. This study provides a baseline of morphometric changes in the three main fibre types following a fixed period of ischaemia and reperfusion. The model may prove useful in the evaluation of pharmacological protection of ischaemic skeletal muscle.