oa Cardiovascular Journal of Africa - Uptake of ^123I-BMIPP in the normal heart with exercise
15-(p-[I23I]-iodophenyl)-3-R,S-methylpentadecanoic acid (123I-BMIPP) is a modified branched fatty acid analogue with relatively slow clearance from the heart which renders it suitable to study myocardial fatty acid metabolism with single photon emission computed tomography (SPECT). Myocardial fatty acid uptake is regulated by a variety of factors, including concentrations of potential substrates, cardiac workload and possible ischaemia. Since these factors could be altered by exercise, the purpose of this study was to compare 123I-BMIPP uptake at rest and with exercise in 10 healthy male volunteers. 123I-BMIPP (185MBq) was administered intravenously followed by planar and tomographic imaging with a dua)-headedscintiHation camera. A geometrical mean method including the triple-energy scatter correction technique was used to quantify myocardia) uptake using the planar images. The mean uptakes with respect to the administered dose for the rest and exercise studies were 4.62 ï¿½ 0.98 % and 3.02 ï¿½ 0.58%, respectively. The mean difference was 1.60 ï¿½ 0.83% and the 95% confidence interval was 1.00 - 2.19%. The global myocardia) uptake of 123I-BMIPP was significantly reduced from rest to exercise, but regional redistribution was not observed during the visual interpretation of the images.
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