oa South African Journal of Chemistry - Phosphoric amides: part 6:1 intramolecular nucleophilic displacement in ?-haloethyl-substituted phosphoramidates



Intramolecular nucleophilic displacement of halide ion from the ?-haloethyl-substituted amidoesters of phosphoric acid was studied under conditons of electrophilic and basic catalysis. 1,3-Substitution by the amide nitrogen atom, leading to the aziridine derivatives, was found to be the preferred reaction pathway; the alternative 1,5-reaction, involving the amide nitrogen or phosphoryl oxygen atoms, was not observed.


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