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oa South African Journal of Chemistry - The efficient synthesis of 2-arylamino-2-imidazolines, 2-heteroaryl-substituted benzimidazoles, and their morpholin-4-ylmethyl derivatives

 

Abstract

2-Heteroaryl-substituted 1-benzimidazoles were synthesized in good yields by heating the HSO adducts of heteroaromatic aldehydes with -phenylenediamine in DMF under reflux. This procedure is more general and shorter than earlier methods. 2-Arylamino-2-imidazolines were prepared by heating dimethyl aryldithioimidocarbonates and ethylenediamine under reflux. The imine-enamine tautomerization of 2-arylamino-2-imidazolines was investigated by means of 1H-NMR spectroscopy. Morpholin-4-ylmethyl derivatives of the benzimidazole and imidazoline products were synthesized regioselectively by treatment with morpholine and formaldehyde.

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/content/chem/55/1/EJC23659
2002-01-01
2016-12-09
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