oa South African Journal of Chemistry - Isolation and crystal structure of 3-aryl-1-(2-hydroxyphenyl)-3-hydroxy-1-propanones derived from Claisen-Schmidt condensation of 2-hydroxyacetophenone with benzaldehyde derivatives

Volume 55, Issue 1
  • ISSN : 0379-4350



2-Hydroxyacetophenone reacted with benzaldehyde derivatives under alkalinic conditions followed by addition of dilute hydrochloric acid solution to afford mixtures of the known 2-hydroxychalcone derivatives and the corresponding previously undescribed 3-aryl-1-(2-hydroxyphenyl)-3-hydroxy-1-propanones. The isolation of the β-hydroxyketone derivatives depends on the work-up conditions. Their structures were established using a combination of NMR, IR and mass spectroscopic techniques. The conformation of the β-hydroxyketones was probed using 1H NMR spectroscopy and X-ray crystallography.

Loading full text...

Full text loading...


Article metrics loading...


This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error