oa South African Journal of Chemistry - Synthesis and antimicrobial activity of new Thiazole-2(3H)-thiones containing 1, 1, 3-trisubstituted Cyclobutane
|Article Title||Synthesis and antimicrobial activity of new Thiazole-2(3H)-thiones containing 1, 1, 3-trisubstituted Cyclobutane|
|© Publisher:||South African Chemical Institute (SACI)|
|Journal||South African Journal of Chemistry|
|Author||Misir Ahmedzade, Cumhur Kirilmis, Alaaddin Cukurovali and Nihat Dilsiz|
|Publication Date||Jan 2003|
|Pages||21 - 24|
|Keyword(s)||1, 3-Thiazole-2(3H)-thiones, [alpha]-Haloketone, Antimicrobial activity, Cyclobutane and Dithiocarbamate|
The reaction of potassium salts of RNHCSSK with 2-chloro-1-(3-methyl-3-phenylcyclobutyl)ethan-1-one in ethanol at 78-80°C afforded new 1, 3-thiazole-2(3<i>H</i>)-thiones containing 1, 1, 3-trisubstituted cyclobutane rings at C-4. The antimicrobial activities of these compounds were also investigated against seven different microorganisms, and some of them were found to be active against several of the microorganisms at higher concentrations.
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