oa South African Journal of Chemistry - Synthesis of the Antimycobacterial Naphthoquinone, 7-Methyljuglone and its Dimer, Neodiospyrin

Volume 59, Issue 1
  • ISSN : 0379-4350



We report on the laboratory-scale synthesis of the antimycobacterial naphthoquinone, 7-methyljuglone (7-methyl-5-hydroxy- 1, 4-naphthoquinone) in a one step Friedel-Crafts acylation reaction. This compound was used to synthesize neodiospyrin, which possesses similar bioactivity.

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