oa South African Journal of Chemistry - Synthesis of the Antimycobacterial Naphthoquinone, 7-Methyljuglone and its Dimer, Neodiospyrin
|Article Title||Synthesis of the Antimycobacterial Naphthoquinone, 7-Methyljuglone and its Dimer, Neodiospyrin|
|© Publisher:||South African Chemical Institute (SACI)|
|Journal||South African Journal of Chemistry|
|Author||Frank Van der Kooy and J.J. Marion Meyer|
|Publication Date||Jan 2006|
|Pages||60 - 61|
|Keyword(s)||7-Methyljuglone, Antimycobacterial, Friedel-Crafts acylation and Neodiospyrin|
We report on the laboratory-scale synthesis of the antimycobacterial naphthoquinone, 7-methyljuglone (7-methyl-5-hydroxy- 1, 4-naphthoquinone) in a one step Friedel-Crafts acylation reaction. This compound was used to synthesize neodiospyrin, which possesses similar bioactivity.
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