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oa South African Journal of Chemistry - Carrier-bound Methotrexate. III. Antiproliferative Activity of Macromolecular MTX Conjugates Against the Human HeLa and Colo Carcinoma Cell Lines

Volume 59, Issue 1
  • ISSN : 0379-4350

 

Abstract

In continuation of studies in these laboratories aiming at the bioevaluation of macromolecular anticancer drug models, cytotoxicity screens are performed on several series of water-soluble polymer-methotrexate conjugates. The methotrexate drug in these conjugates is bound through amide or ester linkages to water-soluble polyamide- or polyamidoamine-type carriers by previously developed anchoring techniques. Tests were conducted against the HeLa human cervical carcinoma cell line generally considered to be drug-sensitive, and against two variants of the rather refractory Colo 320 DM, a human colon adenocarcinoma line.

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/content/chem/59/1/EJC24398
2006-01-01
2017-05-23

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