oa South African Journal of Chemistry - Carrier-bound Methotrexate. III. Antiproliferative Activity of Macromolecular MTX Conjugates Against the Human HeLa and Colo Carcinoma Cell Lines
|Article Title||Carrier-bound Methotrexate. III. Antiproliferative Activity of Macromolecular MTX Conjugates Against the Human HeLa and Colo Carcinoma Cell Lines|
|© Publisher:||South African Chemical Institute (SACI)|
|Journal||South African Journal of Chemistry|
|Author||David D. N'Da, Eberhard Neuse, Margo Nell and Constance E.J. Van Rensburg|
|Publication Date||Jan 2006|
|Pages||33 - 42|
|Keyword(s)||Colo cell line, Drug conjugation, HeLa cell line, Methotrexate, Polyamidoamine and Polyaspartamide|
In continuation of studies in these laboratories aiming at the bioevaluation of macromolecular anticancer drug models, in vitro cytotoxicity screens are performed on several series of water-soluble polymer-methotrexate conjugates. The methotrexate drug in these conjugates is bound through amide or ester linkages to water-soluble polyamide- or polyamidoamine-type carriers by previously developed anchoring techniques. Tests were conducted against the HeLa human cervical carcinoma cell line generally considered to be drug-sensitive, and against two variants of the rather refractory Colo 320 DM, a human colon adenocarcinoma line.
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