oa South African Journal of Chemistry - Tetramethylguanidine (TMG)-catalysed synthesis of α-aminophosphonates by a one-pot reaction
|Article Title||Tetramethylguanidine (TMG)-catalysed synthesis of α-aminophosphonates by a one-pot reaction|
|© Publisher:||South African Chemical Institute (SACI)|
|Journal||South African Journal of Chemistry|
|Author||Arigala Uma Ravi Sankar, B. Siva Kumar, C. Naga Raju and C. Suresh Reddy|
|Publication Date||Jan 2007|
|Pages||125 - 128|
|Keyword(s)||(alpha)-aminophosphonates, Antimicrobial activity, Dialkyl- and arylphosphites, Imines and Tetramethylguanidine (TMG)|
Aldimines (Schiff's bases) undergo nucleophilic addition with diethyl/dimethyl/diphenylphosphite (Pudovik reaction) in the presence of a catalytic amount of tetramethylguanidine (TMG) at ambient temperature to afford the corresponding α-aminophosphonates in high yields. The Schiff's bases were prepared by reacting cinnamaldehyde with substituted amines in refluxing absolute alcohol. The structures of the title compounds were established by elemental analysis and IR, 1H, 13C, 31PNMR and FAB mass spectral data. The antimicrobial activities of these compounds were evaluated and they exhibited significant antimicrobial activity.
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