oa South African Journal of Chemistry - Synthesis of Dinaphtho-dioxaphosphocin-8-oxides, Epoxides and Bisphosphonates
|Article Title||Synthesis of Dinaphtho-dioxaphosphocin-8-oxides, Epoxides and Bisphosphonates|
|© Publisher:||South African Chemical Institute (SACI)|
|Journal||South African Journal of Chemistry|
|Author||Maddali Kasthuraiah, A.U. Ravi Sankar, B. Siva Kumar, C. Suresh Reddy and C. Naga Raju|
|Publication Date||Jan 2007|
|Pages||62 - 66|
|Keyword(s)||Antimicrobial activity, Dioxaphosphocin 8-oxides and Dioxaphosphocin bisphosphonates|
Preparation of 8-substituted-16H-dinaphtho [2, 1-d:1', 2'-g] [1, 3, 2] dioxaphosphocin 8-oxides (5a-g) with an eight-membered phosphorus heterocyclic system (2) and their epoxides and bisphosphonates was accomplished by reacting 8-bromo-dinaphthophosphocin (2) with different mono and bis Grignard reagents (3a-g and 6) followed by oxidation with H2O2. Their structures were confirmed by elemental and spectral (1H, 13C and 31P NMR) data analysis. Some of these compounds are found to possess moderate antimicrobial activity.
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