oa South African Journal of Chemistry - Synthesis of Dinaphtho-dioxaphosphocin-8-oxides, Epoxides and Bisphosphonates

Volume 60, Issue 1
  • ISSN : 0379-4350



Preparation of 8-substituted-16-dinaphtho [2, 1-d:1', 2'-g] [1, 3, 2] dioxaphosphocin 8-oxides (5a-g) with an eight-membered phosphorus heterocyclic system (2) and their epoxides and bisphosphonates was accomplished by reacting 8-bromo-dinaphthophosphocin (2) with different mono and bis Grignard reagents (3a-g and 6) followed by oxidation with HO. Their structures were confirmed by elemental and spectral (1H, 13C and 31P NMR) data analysis. Some of these compounds are found to possess moderate antimicrobial activity.

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