oa South African Journal of Chemistry - Synthesis and antimicrobial activity of some new α-aminophosphonates
|Article Title||Synthesis and antimicrobial activity of some new α-aminophosphonates|
|© Publisher:||South African Chemical Institute (SACI)|
|Journal||South African Journal of Chemistry|
|Author||Kambam Srinivasulu, C. Naga Raju, Y. Hari Babu and A. Lava Kumar Reddy|
|Publication Date||Jan 2007|
|Pages||47 - 51|
|Keyword(s)||[alpha]-Aminophosphonates, Aldehydes, Alkyl/aryl phosphites, Amines and Antimicrobial activity|
Syntheses of new α-aminophosphonates 4a-l were achieved through a one-pot, three-component reaction process (the Kabachnik-Fields reaction). It involves the reaction with substituted salicylaldehydes, amines and dialkyl / diaryl phosphates in dry toluene at reflux temperature. The structures of the novel products were established by elemental analyses, IR, 1H, 13C and 31P NMR and mass spectroscopy. All the title compounds were screened for their antibacterial and antifungal activity. Most of the compounds exhibited moderate antimicrobial activity.
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